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New England Journal of Medicine· 2013Q1

Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>

Jyoti Nangalia, Charles Massie, E. Joanna Baxter, Francesca Nice et al.

Short summary

Somatic mutations in the CALR gene were identified in 70-84% of myeloproliferative neoplasms (MPNs) lacking JAK2 mutations, with 19 distinct variants found in exon 9, leading to a novel C-terminal protein.

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Field: Genetics

GeneticsMedicine