British Journal of Haematology· 2026Q1
CALR ‐mutated myeloproliferative neoplasms: Refining molecular risk beyond the driver
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- Q1SCImago
- 2026year
Short summary
Additional somatic mutations in CALR-mutated myeloproliferative neoplasms (MPNs) refine risk stratification beyond the CALR driver mutation alone, impacting long-term outcomes in essential thrombocythaemia and myelofibrosis.
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Key points
- CALR-mutated MPNs show considerable heterogeneity in disease course despite generally favorable outcomes.
- Additional somatic mutations, beyond the CALR driver, are identified as having prognostic relevance.
- These molecular findings refine risk stratification for patients with essential thrombocythaemia and myelofibrosis.
- The study highlights the need to consider co-mutational context for predicting MPN outcomes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Calreticulin ( CALR )‐mutated myeloproliferative neoplasms (MPNs) are generally associated with favourable outcomes, yet considerable heterogeneity persists across the disease course. Mawalkar et al. provide long‐term data across essential thrombocythaemia (ET), post‐ET myelofibrosis (MF) and primary MF, highlighting the prognostic relevance of additional somatic mutations. The contribution of co‐mutational context, variant allele frequency (VAF), disease origin and timing of molecular assessment remains incompletely defined. Commentary on: Mawalkar et al. Outcome heterogeneity in CALR‐mutated myeloproliferative neoplasms. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70859 .
The authors' abstract, as published at the source. British Journal of Haematology, 2026 · DOI ↗
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Field: Genetics (Medicine)
GeneticsMedicine