Antioxidants and Redox Signaling· 2017Q1· Review
The Role of Sirtuins in Antioxidant and Redox Signaling
- 817citations
- Q1SCImago
- 2017year
Short summary
Sirtuins (SIRTs 1-7) are NAD-dependent deacetylases that critically regulate antioxidant and redox signaling (ARS) pathways, with specific sirtuins protecting against ROS (SIRT1, SIRT3, SIRT5) or modulating oxidative stress genes (SIRT2, SIRT6, SIRT7), while SIRT4 exhibits dual roles in ROS production and antioxidation.
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