Molecules and Cells· 2016Q1
Sirt1 and the Mitochondria
- 729citations
- Q1SCImago
- 2016year
Short summary
Sirt1 deacetylates PGC-1α, promoting mitochondrial biogenesis and turnover via mitophagy, which may explain its role in caloric restriction and longevity.
AI-generated from the title and abstract; the full text is not read.
Key points
- Sirt1 deacetylates PGC-1α, influencing mitochondrial biogenesis.
- This deacetylation is linked to Sirt1's role in caloric restriction and longevity.
- Sirt1 also regulates mitochondrial turnover through mitophagy.
- These mechanisms collectively impact cellular physiology and disease.
AI-generated from the title and abstract; the full text is not read.
Abstract
Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1α (PGC-1α) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1's role in caloric restriction and impacts on longevity. The notion of Sirt1's regulation of PGC-1α activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1's regulation of mitochondrial biogenesis and turnover, in relation to PGC-1α deacetylation and various aspects of cellular physiology and disease.
The authors' abstract, as published at the source. Molecules and Cells, 2016 · DOI ↗
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Field: Geriatrics and Gerontology
Geriatrics and GerontologyMedicine