Cold Spring Harbor Perspectives in Biology· 2014Q1· Preprint
IL-6 in Inflammation, Immunity, and Disease
- 4,995citations
- Q1SCImago
- 2014year
Short summary
Interleukin-6 (IL-6) is crucial for host defense against infection and injury, but its dysregulated synthesis drives chronic inflammation and autoimmunity.
AI-generated from the title and abstract; the full text is not read.
Key points
- IL-6 is essential for immediate host defense responses.
- Dysregulated IL-6 synthesis is a pathological driver of chronic inflammation and autoimmunity.
- Tocilizumab, an anti-IL-6 receptor antibody, is approved for rheumatoid and juvenile idiopathic arthritis.
- Further research into IL-6 synthesis mechanisms is needed for more targeted therapies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictly controlled by transcriptional and posttranscriptional mechanisms, dysregulated continual synthesis of IL-6 plays a pathological effect on chronic inflammation and autoimmunity. For this reason, tocilizumab, a humanized anti-IL-6 receptor antibody was developed. Various clinical trials have since shown the exceptional efficacy of tocilizumab, which resulted in its approval for the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. Moreover, tocilizumab is expected to be effective for other intractable immune-mediated diseases. In this context, the mechanism for the continual synthesis of IL-6 needs to be elucidated to facilitate the development of more specific therapeutic approaches and analysis of the pathogenesis of specific diseases.
The authors' abstract, as published at the source. Cold Spring Harbor Perspectives in Biology, 2014 · DOI ↗
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Field: Hematology
HematologyMedicine