Science· 2014Q1
Neutrophils scan for activated platelets to initiate inflammation
- 650citations
- Q1SCImago
- 2014year
Short summary
Neutrophils scan for activated platelets in the bloodstream by organizing a protruding domain that engages them, a process crucial for initiating inflammation and leukocyte migration.
AI-generated from the title and abstract; the full text is not read.
Key points
- Neutrophils polarize to form a protruding domain that engages activated platelets in the bloodstream.
- The selectin ligand PSGL-1 transduces signals from platelet interactions, driving neutrophil receptor redistribution.
- Neutrophils unable to polarize or signal via PSGL-1 show impaired crawling and leukocyte migration.
- Blocking this neutrophil-platelet engagement protected mice from thromboinflammatory injury.
AI-generated from the title and abstract; the full text is not read.
Abstract
Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.
The authors' abstract, as published at the source. Science, 2014 · DOI ↗
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Field: Immunology and Allergy
Immunology and AllergyMedicine