Tumor Biology· 2013Q2
Collagen as a double-edged sword in tumor progression
- 604citations
- Q2SCImago
- 2013year
Short summary
Collagen, traditionally viewed as a tumor barrier, actively promotes tumor progression by releasing biomechanical signals that trigger infiltration, angiogenesis, invasion, and migration.
AI-generated from the title and abstract; the full text is not read.
Key points
- Collagen actively promotes tumor progression, not just passively resists it.
- Collagen remodeling and deposition release biomechanical signals.
- These signals trigger tumor infiltration, angiogenesis, invasion, and migration.
- Collagen acts as a 'double-edged sword,' potentially inhibiting and promoting tumor growth at different stages.
AI-generated from the title and abstract; the full text is not read.
Abstract
It has been recognized that cancer is not merely a disease of tumor cells, but a disease of imbalance, in which stromal cells and tumor microenvironment play crucial roles. Extracellular matrix (ECM) as the most abundant component in tumor microenvironment can regulate tumor cell behaviors and tissue tension homeostasis. Collagen constitutes the scaffold of tumor microenvironment and affects tumor microenvironment such that it regulates ECM remodeling by collagen degradation and re-deposition, and promotes tumor infiltration, angiogenesis, invasion and migration. While collagen was traditionally regarded as a passive barrier to resist tumor cells, it is now evident that collagen is also actively involved in promoting tumor progression. Collagen changes in tumor microenvironment release biomechanical signals, which are sensed by both tumor cells and stromal cells, trigger a cascade of biological events. In this work, we discuss how collagen can be a double-edged sword in tumor progression, both inhibiting and promoting tumor progression at different stages of cancer development.
The authors' abstract, as published at the source. Tumor Biology, 2013 · DOI ↗
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Field: Immunology and Allergy
Immunology and AllergyMedicine