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FEBS Journal· 2013Q1

Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?

Pura Muñoz‐Cánoves, Camilla Schéele, Bente Klarlund Pedersen, Antonio L. Serrano

Short summary

Skeletal muscle produces and responds to Interleukin-6 (IL-6), a myokine with contradictory roles in muscle growth and wasting.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Skeletal muscle produces and is a target for Interleukin-6 (IL-6).
  • IL-6 signaling can stimulate muscle hypertrophy and myogenesis via muscle stem cells.
  • IL-6 also plays a role in regulating energy metabolism during muscle contraction.
  • Paradoxically, IL-6 has also been implicated in promoting muscle atrophy and wasting.

AI-generated from the title and abstract; the full text is not read.

Abstract

Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL-6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL-6. Paradoxically, deleterious actions for IL-6 have also been proposed, such as promotion of atrophy and muscle wasting. We review the current evidence for these apparently contradictory effects, the mechanisms involved and discuss their possible biological implications.

The authors' abstract, as published at the source. FEBS Journal, 2013 · DOI ↗

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