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Disability and Rehabilitation· 2026Q1· Review

Safety and effectiveness of exercise interventions for kinesiophobia in patients with cardiovascular disease: a systematic review and meta-analysis

Xinglin Zheng, Huina Zou, Yijingxuan Fan, Peihuang Dong et al.

Short summary

Exercise interventions reduce kinesiophobia in cardiovascular patients, but safety data is limited and evidence is heterogeneous.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Exercise interventions significantly reduce kinesiophobia in cardiovascular disease patients.
  • Safety data for exercise interventions in this population is currently inadequate.
  • All included studies were rated as having a moderate risk of bias.
  • Heterogeneity across studies limits definitive conclusions and exercise recommendations.

AI-generated from the title and abstract; the full text is not read.

Abstract

PURPOSE: To evaluate the effectiveness and safety of exercise interventions for kinesiophobia in patients with cardiovascular disease. METHODS: The system searched eight databases, covering periods from database creation to November 27, 2025. The RoB 2.0 and the ROBINS-I were used to assess the quality of the study. Meta-analysis was performed using Review Manager 5.4 software with random-effects models, supplemented by subgroup analyses and sensitivity analyses to explore sources of heterogeneity. RESULTS: = 93%), although all included studies were rated as having moderate risk of bias. Based on the limited available data (2 of 10 studies), the existing dataset is inadequate to form robust, generalizable judgments about the safety profile of exercise interventions for this population. Exploratory subgroup analyses detected numerical differences in pooled effect sizes across different exercise parameters, yet these observational trends cannot support definitive exercise recommendations due to small sample sizes. CONCLUSION: Exercise to reduced kinesiophobia in cardiovascular patients, limited safety records and substantial heterogeneity across moderate-quality evidence restrict definitive inferences. REPORTING METHODOLOGY: PRISMA 2020 statement. PROSPERO REGISTRATION NUMBER: CRD42025646414.

The authors' abstract, as published at the source. Disability and Rehabilitation, 2026 · DOI ↗

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Field: Complementary and alternative medicine

Complementary and alternative medicineMedicine