PLoS ONE· 2015Q1

Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

Jennifer E. Huffman, Eva Albrecht, Alexander Teumer, Massimo Mangino et al.

1,234citations
Q1SCImago
2015year

Short summary

Genome-wide analyses in up to 42,569 participants reveal that body mass index (BMI) significantly modulates the effect of genetic variants on serum urate levels, with a novel SNP at RBFOX3 reaching genome-wide significance for this interaction.

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Field: Nephrology

NephrologyMedicine