Inorganic Chemistry· 2026Q1
Design Principles to Promote Acid–Base Interactions with a Weak Second-Sphere Lewis Acid
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- 2026year
Short summary
A new design strategy using a BPin-appended NHC scaffold with a shortened tether enables cooperative binding with weak Lewis acids, enhancing substrate interaction.
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Key points
- A design strategy was developed to enable cooperative binding with weak Lewis acids like BPin.
- The strategy involves appending BPin to an NHC scaffold.
- A shortened tether enhances preorganization and facilitates substrate binding.
- Experimental and computational analyses confirmed the design principles.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Boronic esters such as BPin are underutilized in secondary-sphere chemistry due to their weak acidity. We report a design strategy to enable cooperative binding with a BPin-appended NHC scaffold. Employing a shortened tether enhances preorganization and facilitates substrate binding in tandem with the metal center. Experimental and computational analyses clarify principles of the design that enable cooperativity.
The authors' abstract, as published at the source. Inorganic Chemistry, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry