Journal of Clinical Oncology· 2014Q1
Human Papillomavirus and Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma
- 549citations
- Q1SCImago
- 2014year
Short summary
Patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have significantly better overall survival (OS) after disease progression compared to those with HPV-negative OPSCC (2-year OS: 54.6% vs. 27.6%).
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Key points
- HPV-positive OPC patients had a 2-year overall survival rate of 54.6% after progression, versus 27.6% for HPV-negative patients.
- Median survival after progression was 2.6 years for HPV-positive OPC and 0.8 years for HPV-negative OPC (P < .001).
- HPV (p16-positive) status was an independent predictor of reduced risk of death after progression (HR, 0.48).
- Receipt of salvage surgery also reduced the risk of death after progression (HR, 0.48).
AI-generated from the title and abstract; the full text is not read.
Abstract
PURPOSE: Risk of cancer progression is reduced for patients with human papillomavirus (HPV) -positive oropharynx cancer (OPC) relative to HPV-negative OPC, but it is unknown whether risk of death after progression is similarly reduced. PATIENTS AND METHODS: Patients with stage III-IV OPC enrolled onto Radiation Therapy Oncology Group trials 0129 or RTOG 0522 who had known tumor p16 status plus local, regional, and/or distant progression after receiving platinum-based chemoradiotherapy were eligible for a retrospective analysis of the association between tumor p16 status and overall survival (OS) after disease progression. Rates were estimated by Kaplan-Meier method and compared by log-rank; hazard ratios (HRs) were estimated by Cox models. Tests and models were stratified by treatment protocol. RESULTS: A total of 181 patients with p16-positive (n = 105) or p16-negative (n = 76) OPC were included in the analysis. Patterns of failure and median time to progression (8.2 v 7.3 months; P = .67) were similar for patients with p16-positive and p16-negative tumors. After a median follow-up period of 4.0 years after disease progression, patients with p16-positive OPC had significantly improved survival rates compared with p16-negative patients (2-year OS, 54.6% v 27.6%; median, 2.6 v 0.8 years; P < .001). p16-positive tumor status (HR, 0.48; 95% CI, 0.31 to 0.74) and receipt of salvage surgery (HR, 0.48; 95% CI; 0.27 to 0.84) reduced risk of death after disease progression whereas distant versus locoregional progression (HR, 1.99; 95% CI, 1.28 to 3.09) increased risk, after adjustment for tumor stage and cigarette pack-years at enrollment. CONCLUSION: Tumor HPV status is a strong and independent predictor of OS after disease progression and should be a stratification factor for clinical trials for patients with recurrent or metastatic OPC.
The authors' abstract, as published at the source. Journal of Clinical Oncology, 2014 · DOI ↗
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Field: Otorhinolaryngology
OtorhinolaryngologyMedicine