Journal of Clinical Oncology· 2015Q1
Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective
- 851citations
- Q1SCImago
- 2015year
Short summary
Despite advances in radiotherapy yielding excellent local control for nasopharyngeal carcinoma (NPC), distant failure remains a key challenge, driving research into novel biomarkers and drug targets.
AI-generated from the title and abstract; the full text is not read.
Key points
- Modern radiotherapy achieves excellent local control for nasopharyngeal carcinoma (NPC).
- Distant failure remains the primary challenge in NPC patient prognosis.
- Molecular research is identifying novel biomarkers and drug targets for NPC.
- Epstein-Barr virus is linked to the molecular pathogenesis of NPC.
AI-generated from the title and abstract; the full text is not read.
Abstract
Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. Advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngeal carcinoma as well as its etiologic association with the Epstein-Barr virus. This in turn has led to the discovery of novel biomarkers and drug targets, rendering this cancer site a current focus for new drug development. This article reviews and appraises the key literature on the current management of nasopharyngeal carcinoma and future directions in clinical research.
The authors' abstract, as published at the source. Journal of Clinical Oncology, 2015 · DOI ↗
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Field: Otorhinolaryngology
OtorhinolaryngologyMedicine