Deintensification Candidate Subgroups in Human Papillomavirus–Related Oropharyngeal Cancer According to Minimal Risk of Distant Metastasis

Short summary

HPV-positive oropharyngeal cancer patients with T1-3N0-2c staging have a low distant metastasis (DM) risk, but those with N2c substage show reduced distant control (DC) with radiotherapy (RT) alone (73%) versus chemoradiotherapy (CRT) (92%), suggesting they are less suited for deintensification strategies omitting chemotherapy.

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