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Journal of Clinical Oncology· 2017Q1

E1308: Phase II Trial of Induction Chemotherapy Followed by Reduced-Dose Radiation and Weekly Cetuximab in Patients With HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx— ECOG-ACRIN Cancer Research Group

Shanthi Marur, Shuli Li, Anthony J. Cmelak, Maura L. Gillison et al.

Short summary

In HPV-associated oropharyngeal cancer, induction chemotherapy followed by reduced-dose radiation (54 Gy) and weekly cetuximab achieved 80% 2-year progression-free survival in responders, with significantly fewer swallowing and nutritional issues compared to higher doses.

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Field: Otorhinolaryngology

OtorhinolaryngologyMedicine