Dalton Transactions· 2018Q2
The side effects of platinum-based chemotherapy drugs: a review for chemists
- 1,692citations
- Q2SCImago
- 2018year
Short summary
Platinum-based chemotherapy drugs (cisplatin, carboplatin, oxaliplatin) cause around 40 severe, dose-limiting side effects, requiring dose reductions of 25-100% and extensive patient monitoring.
AI-generated from the title and abstract; the full text is not read.
Key points
- Platinum drugs (cisplatin, carboplatin, oxaliplatin) are effective cancer treatments but cause ~40 severe side effects.
- Dose-limiting toxicities are nephrotoxicity (cisplatin), myelosuppression (carboplatin), and neurotoxicity (oxaliplatin).
- Side effects can lead to 25-100% dose reductions in chemotherapy.
- Patients require extensive monitoring and co-prescription of drugs to manage side effects.
AI-generated from the title and abstract; the full text is not read.
Abstract
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. The dose-limiting side effect for cisplatin is nephrotoxicity, for carboplatin it is myelosuppression, and for oxaliplatin it is neurotoxicity. Other common side effects include anaphylaxis, cytopenias (including leukopenia and neutropenia, thrombocytopenia, and anaemia), hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, and asthenia. The side effects may require patients to be prescribed dose reductions in their platinum drugs of between 25 and 100%. Furthermore, patients require extensive monitoring of their biochemistries, kidney and liver function, and depending on the drug, hearing tests. Finally, patients are commonly co-prescribed additional non-chemotherapy based drugs to treat the side effects which can include antiemetics, antibiotics and myeloid growth factors, mannitol, propafenone, saline hyperhydration, magnesium supplements, monoclonal antibody cytokine blockers, and antioxidants.
The authors' abstract, as published at the source. Dalton Transactions, 2018 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine