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Annual Review of Biochemistry· 2017Q1· Review

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

Fabrizio Chiti, Christopher M. Dobson

Short summary

Proteins can misfold into amyloid aggregates, linked to diseases like Alzheimer's, Parkinson's, and type II diabetes, with recent advances clarifying fibril structures, formation mechanisms, and the role of proteostasis networks.

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Field: Physiology

PhysiologyMedicine