Science· 2017Q1· Review
Inflammation and metabolism in tissue repair and regeneration
- 1,327citations
- Q1SCImago
- 2017year
Short summary
This review synthesizes current understanding of how inflammation and cell metabolism orchestrate tissue repair, highlighting how dysregulation leads to fibrosis and impaired function.
AI-generated from the title and abstract; the full text is not read.
Key points
- Tissue repair is metabolically demanding and relies on a well-orchestrated inflammatory response.
- Dysregulated inflammation can result in chronic wounds or fibrosis, impairing tissue function.
- Aberrant accumulation of collagenous connective tissue defines fibrosis.
- Understanding inflammation-metabolism interplay offers potential therapeutic avenues.
AI-generated from the title and abstract; the full text is not read.
Abstract
Tissue repair after injury is a complex, metabolically demanding process. Depending on the tissue's regenerative capacity and the quality of the inflammatory response, the outcome is generally imperfect, with some degree of fibrosis, which is defined by aberrant accumulation of collagenous connective tissue. Inflammatory cells multitask at the wound site by facilitating wound debridement and producing chemokines, metabolites, and growth factors. If this well-orchestrated response becomes dysregulated, the wound can become chronic or progressively fibrotic, with both outcomes impairing tissue function, which can ultimately lead to organ failure and death. Here we review the current understanding of the role of inflammation and cell metabolism in tissue-regenerative responses, highlight emerging concepts that may expand therapeutic perspectives, and briefly discuss where important knowledge gaps remain.
The authors' abstract, as published at the source. Science, 2017 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine