International Journal of Molecular Sciences· 2016Q1
Inflammation in Chronic Wounds
- 1,151citations
- Q1SCImago
- 2016year
Short summary
Chronic wounds are characterized by prolonged inflammation that disrupts the normal healing process, driven by factors like aging, hypoxia, and bacterial colonization.
AI-generated from the title and abstract; the full text is not read.
Key points
- Chronic wounds impose substantial biological, psychological, social, and financial burdens.
- Pathologically extensive inflammation is a key factor disrupting the normal healing cascade in chronic wounds.
- Factors like aging, hypoxia, ischemia-reperfusion injury, and bacterial colonization contribute to a rogue inflammatory response.
- Current treatments include debridement, dressings, and antibiotics, with pharmaceutical adjuncts under investigation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2016 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine