Journal of Wound Care· 2013Q2
Wound healing and the role of fibroblasts
- 781citations
- Q2SCImago
- 2013year
Short summary
Fibroblasts are essential for wound healing, performing critical roles including fibrin clot breakdown, extracellular matrix and collagen deposition, and wound contraction.
AI-generated from the title and abstract; the full text is not read.
Key points
- Fibroblasts initiate wound healing by breaking down the fibrin clot.
- They deposit extracellular matrix and collagen to support new tissue formation.
- Fibroblasts are responsible for wound contraction, closing the defect.
- Local wound conditions regulate fibroblast activation and activity throughout healing.
AI-generated from the title and abstract; the full text is not read.
Abstract
Fibroblasts are critical in supporting normal wound healing, involved in key processes such as breaking down the fibrin clot, creating new extra cellular matrix (ECM) and collagen structures to support the other cells associated with effective wound healing, as well as contracting the wound. This article explores and summarises the research evidence on the role of fibroblasts, their origins and activation, and how they navigate the wound bed, as well as how their activity leads to wound contraction. This article also explores the local conditions at the wound site, which activate, regulate and ultimately reduce the fibroblast activity as the skin's integrity returns on healing.
The authors' abstract, as published at the source. Journal of Wound Care, 2013 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Rehabilitation
RehabilitationMedicine