Bioengineering· 2021Q2
Collagen in Wound Healing
- 948citations
- Q2SCImago
- 2021year
Short summary
Collagen, a vital extracellular matrix component, actively regulates the inflammatory, proliferative, and remodeling phases of wound healing, and its use as an adjunct therapy can promote healing in chronic wounds.
AI-generated from the title and abstract; the full text is not read.
Key points
- Collagen is a primary component of the extracellular matrix and regulates wound healing phases.
- Chronic wounds exhibit persistent inflammation and ECM degradation, hindering natural healing.
- Collagen-based products are used as adjunct therapies to promote healing in chronic wounds.
- The review synthesizes literature on collagen's biological roles and therapeutic applications in wound care.
AI-generated from the title and abstract; the full text is not read.
Abstract
Normal wound healing progresses through inflammatory, proliferative and remodeling phases in response to tissue injury. Collagen, a key component of the extracellular matrix, plays critical roles in the regulation of the phases of wound healing either in its native, fibrillar conformation or as soluble components in the wound milieu. Impairments in any of these phases stall the wound in a chronic, non-healing state that typically requires some form of intervention to guide the process back to completion. Key factors in the hostile environment of a chronic wound are persistent inflammation, increased destruction of ECM components caused by elevated metalloproteinases and other enzymes and improper activation of soluble mediators of the wound healing process. Collagen, being central in the regulation of several of these processes, has been utilized as an adjunct wound therapy to promote healing. In this work the significance of collagen in different biological processes relevant to wound healing are reviewed and a summary of the current literature on the use of collagen-based products in wound care is provided.
The authors' abstract, as published at the source. Bioengineering, 2021 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine