Science· 2012Q1
Unlike Bone, Cartilage Regeneration Remains Elusive
- 1,188citations
- Q1SCImago
- 2012year
Short summary
Articular cartilage regeneration has proven significantly more challenging than bone, vasculature, or cardiac tissue repair, despite cartilage's simpler cellular structure.
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Key points
- Articular cartilage regeneration has lagged behind bone, vasculature, and cardiac tissue repair.
- Key challenges include cell source selection, scaffold design, biomechanical suitability, and native tissue integration.
- Cartilage requires engineering of tissues with superior mechanical properties for harsh physiological conditions.
AI-generated from the title and abstract; the full text is not read.
Abstract
Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.
The authors' abstract, as published at the source. Science, 2012 · DOI ↗
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Field: Rheumatology
RheumatologyMedicine