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Clinical Cancer Research· 2014Q1

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

Derek A. Wainwright, Alan L. Chang, Mahua Dey, Irina V. Balyasnikova et al.

Short summary

Combinatorial blockade of IDO, CTLA-4, and PD-L1 in mice with established gliomas resulted in 100% long-term survival, significantly reducing tumor-infiltrating regulatory T cells.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience