Cancer Research· 2012Q1· Review

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

Michael Platten, Wolfgang Wick, Benoı̂t J. Van den Eynde

701citations
Q1SCImago
2012year

Short summary

Tryptophan catabolism in tumors suppresses antitumor immunity via tryptophan depletion and accumulation of immunosuppressive catabolites like kynurenine, which signals through the aryl hydrocarbon receptor.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience