Current Neuropharmacology· 2014Q1· Review
Oxidative Stress and Psychological Disorders
- 559citations
- Q1SCImago
- 2014year
Short summary
Oxidative stress, an imbalance of reactive oxygen species and antioxidants, is strongly linked to major psychological disorders like depression, anxiety, schizophrenia, and bipolar disorder.
AI-generated from the title and abstract; the full text is not read.
Key points
- The brain is highly susceptible to oxidative stress due to high oxygen consumption and lipid content.
- Oxidative stress is implicated in depression, anxiety disorders, schizophrenia, and bipolar disorder.
- Recent discoveries link oxidative status to these specific mental health conditions.
- The causal relationship between oxidative stress and psychiatric diseases requires further investigation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Oxidative stress is an imbalance between cellular production of reactive oxygen species and the counteracting antioxidant mechanisms. The brain with its high oxygen consumption and a lipid-rich environment is considered highly susceptible to oxidative stress or redox imbalances. Therefore, the fact that oxidative stress is implicated in several mental disorders including depression, anxiety disorders, schizophrenia and bipolar disorder, is not surprising. Although several elegant studies have established a link between oxidative stress and psychiatric disorders, the causal relationship between oxidative stress and psychiatric diseases is not fully determined. Another critical aspect that needs much attention and effort is our understanding of the association between cellular oxidative stress and emotional stress. This review examines some of the recent discoveries that link oxidative status with anxiety, depression, schizophrenia and bipolar disorder. A discussion of published results and questions that currently exist in the field regarding a causal relationship between oxidative and emotional stress is also provided.
The authors' abstract, as published at the source. Current Neuropharmacology, 2014 · DOI ↗
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Field: Biological Psychiatry
Biological PsychiatryNeuroscience