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Scientific Reports· 2013Q1

Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target

Gabriel Gasque, Stephen Conway, Juan Huang, Yi Rao et al.

Short summary

A high-throughput screen of 3630 small molecules in fruit fly larvae identified metitepine as a potent appetite suppressant, acting specifically through the 5HT2A receptor.

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Field: Cellular and Molecular Neuroscience

Cellular and Molecular NeuroscienceNeuroscience