ACS Applied Nano Materials· 2026Q1
Lignin-Mediated In Situ Silver Nanoparticle Bioactive Conductive Hydrogels for Regenerative Wound Healing, Energy Harvesting, and Motion Sensing Applications
- 0citations
- Q1SCImago
- 2026year
Short summary
New lignin-silver nanoparticle-polyacrylamide (lignin-AgNP-PAM) hydrogels show high antioxidant (88% ABTS scavenging), antibacterial (87% inhibition), and biocompatible (85% fibroblast viability) properties, alongside electromechanical performance (up to 28V triboelectric output).
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Key points
- Lignin facilitates in situ formation and stabilization of silver nanoparticles within polyacrylamide hydrogels.
- Hydrogels exhibit strong antioxidant (88% ABTS scavenging) and antibacterial (87% inhibition) activities.
- Human dermal fibroblast viability remained above 85%, with enhanced fibroblast migration showing up to 92% wound closure.
- Electromechanical testing demonstrated triboelectric output up to 28V and distinct deformation-responsive signals for motion sensing.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract In this study, lignin−silver nanoparticle−polyacrylamide (lignin−AgNP−PAM) hybrid hydrogels were developed through persulfate-initiated free-radical polymerization for wound dressing, energy harvesting, and motion-sensing applications. Kraft lignin and milled wood lignin were incorporated at two different loadings to evaluate the formulation-dependent physicochemical, biological, and electromechanical performance. Lignin acted as a bioactive component and was proposed to assist the in situ formation and stabilization of AgNPs through its redox-active phenolic groups. FTIR analysis supported lignin incorporation and molecular interactions within the PAM network, while XRD indicated reduced semi-crystallinity following lignin addition and possible metallic silver formation in selected samples. Dynamic light scattering revealed lignin−silver hybrid particles with Z-average sizes ranging from 74 nm to 298 nm and polydispersity indices of 0.28−0.39. The hydrogels exhibited strong antioxidant activity, reaching approximately 88% ABTS radical-scavenging efficiency, and produced more than 87% antibacterial inhibition against Escherichia coli and Staphylococcus aureus under the tested conditions. Human dermal fibroblast viability remained above 85%, while M3 showed the highest viability and the lowest hemolysis, approximately 100% and 10%, respectively. Scratch assays demonstrated enhanced fibroblast migration, with K3 and M2 achieving approximately 90% and 92% wound closure, respectively, after 48 h. Proof-of-concept electromechanical testing of K2 generated triboelectric output up to approximately 28 V and distinct deformation-responsive signals near 1 V during finger motion. Overall, the hydrogels showed formulation-dependent trade-offs between bioactivity, blood compatibility, and electrical performance, supporting further optimization for wound contact and wearable sensing applications.
The authors' abstract, as published at the source. ACS Applied Nano Materials, 2026 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine