Anais Brasileiros de Dermatologia· 2016Q2· Review
Wound healing - A literature review
- 1,579citations
- Q2SCImago
- 2016year
Short summary
This review synthesizes the sequential molecular and cellular events involved in skin wound healing, detailing the exudative, proliferative, and remodeling phases.
AI-generated from the title and abstract; the full text is not read.
Key points
- Wound healing involves sequential exudative, proliferative, and remodeling phases.
- The proliferative stage includes myofibroblast contraction, angiogenesis, and reepithelialization.
- Signaling proteins, like the Hedgehog pathway, are crucial for orchestrating cellular differentiation and repair.
- Endothelial cells can differentiate into mesenchymal components during healing.
AI-generated from the title and abstract; the full text is not read.
Abstract
Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
The authors' abstract, as published at the source. Anais Brasileiros de Dermatologia, 2016 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine