eLife· 2014Q1
The neuronal architecture of the mushroom body provides a logic for associative learning
- 1,175citations
- Q1SCImago
- 2014year
Short summary
A comprehensive map of Drosophila mushroom body neurons reveals 15 distinct compartments formed by segregated dendritic arbors of 21 MB output neuron types along Kenyon cell axons, with dopaminergic neurons targeting specific compartments to enable valence assignment in associative olfactory learning.
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Key points
- Identified 21 types of mushroom body output neurons (MBONs) and mapped their connections.
- MBON dendrites form 15 distinct compartments within the mushroom body lobes, tiling along Kenyon cell axons.
- 20 types of dopaminergic neurons (DANs) target specific MBON compartments.
- This compartmentalized structure provides a substrate for associative olfactory learning and memory by imposing valence on sensory representations.
AI-generated from the title and abstract; the full text is not read.
Abstract
We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell-MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.
The authors' abstract, as published at the source. eLife, 2014 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience