Science· 2015Q1
Electronic dura mater for long-term multimodal neural interfaces
- 1,074citations
- Q1SCImago
- 2015year
Short summary
Researchers developed a flexible, brain-tissue-like electronic implant, dubbed 'e-dura', that integrates electrodes and chemical delivery systems for long-term neural interfacing.
AI-generated from the title and abstract; the full text is not read.
Key points
- Developed 'e-dura', a soft electronic implant matching brain tissue elasticity.
- e-dura integrates interconnects, electrodes, and chemotrodes for multimodal function.
- The implant sustains millions of stretch cycles, electrical pulses, and chemical injections.
- Demonstrated cortical state recording in freely behaving animals for brain-machine interfaces.
- Restored locomotion in paralyzed animals via electrochemical spinal neuromodulation.
AI-generated from the title and abstract; the full text is not read.
Abstract
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.
The authors' abstract, as published at the source. Science, 2015 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience