Science· 2020Q1
Glymphatic failure as a final common pathway to dementia
- 1,064citations
- Q1SCImago
- 2020year
Short summary
Glymphatic system failure, which clears brain waste products, may be a final common pathway to dementia, linked to age-related sleep disruption.
AI-generated from the title and abstract; the full text is not read.
Key points
- The glymphatic system clears brain waste products and is primarily active during sleep.
- Sleep quality declines with age, and its disruption is a frequent precursor to dementia.
- Glymphatic system function degrades with age, suggesting a link to sleep disturbance and dementia progression.
- Glymphatic failure may be a final common pathway for various neurodegenerative diseases.
AI-generated from the title and abstract; the full text is not read.
Abstract
Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.
The authors' abstract, as published at the source. Science, 2020 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience