BioMed Research International· 2014Q2· Review
Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies
- 1,048citations
- Q2SCImago
- 2014year
Short summary
Current peripheral nerve repair techniques, unchanged for over 60 years, result in incomplete recovery for over half of patients, despite advances in understanding nerve regeneration.
AI-generated from the title and abstract; the full text is not read.
Key points
- Less than 50% of patients achieve good or excellent motor/sensory function after current peripheral nerve repair.
- Surgical techniques for nerve reconstruction have remained largely unchanged for over 60 years.
- Knowledge of nerve physiology and regeneration outpaces current surgical abilities.
- Experimental strategies in molecular biology and bioengineering aim to overcome regeneration barriers.
AI-generated from the title and abstract; the full text is not read.
Abstract
Unlike other tissues in the body, peripheral nerve regeneration is slow and usually incomplete. Less than half of patients who undergo nerve repair after injury regain good to excellent motor or sensory function and current surgical techniques are similar to those described by Sunderland more than 60 years ago. Our increasing knowledge about nerve physiology and regeneration far outweighs our surgical abilities to reconstruct damaged nerves and successfully regenerate motor and sensory function. It is technically possible to reconstruct nerves at the fascicular level but not at the level of individual axons. Recent surgical options including nerve transfers demonstrate promise in improving outcomes for proximal nerve injuries and experimental molecular and bioengineering strategies are being developed to overcome biological roadblocks limiting patient recovery.
The authors' abstract, as published at the source. BioMed Research International, 2014 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience