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The Journal of Physiology· 2016Q1

The repair Schwann cell and its function in regenerating nerves

Kristján R. Jessen, Rhona Mirsky

Short summary

Schwann cells, crucial for nerve regeneration, reprogram into a repair phenotype post-injury, characterized by myelin clearance, immune response activation, and formation of regeneration tracks (Bungner's bands). This reprogramming is transcriptionally controlled by c-Jun, which is essential for functional recovery.

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Field: Cellular and Molecular Neuroscience

Cellular and Molecular NeuroscienceNeuroscience