Science· 2015Q1
Principles of connectivity among morphologically defined cell types in adult neocortex
- 1,007citations
- Q1SCImago
- 2015year
Short summary
A census of over 11,000 neuron pairs in adult neocortex revealed 15 interneuron types, each with distinct connectivity patterns, suggesting a few core motifs define the neocortical microcircuit.
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Key points
- Identified 15 distinct interneuron types in adult neocortex layers 1, 2/3, and 5.
- Mapped connectivity patterns for over 11,000 pairs of morphologically and electrophysiologically identified neurons.
- Each interneuron type exhibits a characteristic connectivity profile with other interneurons and pyramidal cells.
- The neocortical microcircuit's structure can be described by a small number of recurring connectivity motifs.
AI-generated from the title and abstract; the full text is not read.
Abstract
Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.
The authors' abstract, as published at the source. Science, 2015 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience