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Cell Reports· 2015Q1

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

Keiko Muguruma, Ayaka Nishiyama, Hideshi Kawakami, Kouichi Hashimoto et al.

Short summary

Human pluripotent stem cells spontaneously self-organize in 3D culture to form a polarized cerebellar structure, generating functional Purkinje cells and mimicking early embryonic cerebellar development.

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Field: Developmental Neuroscience

Developmental NeuroscienceNeuroscience