Science· 2016Q1
Oligodendrocyte precursors migrate along vasculature in the developing nervous system
- 481citations
- Q1SCImago
- 2016year
Short summary
Oligodendrocyte precursor cells (OPCs) use blood vessels as a physical track for migration in the developing brain and spinal cord, a process essential for myelination.
AI-generated from the title and abstract; the full text is not read.
Key points
- Oligodendrocyte precursor cells (OPCs) associate with the abluminal surface of blood vessels in the developing brain and spinal cord.
- OPCs migrate by crawling along and jumping between blood vessels.
- Impaired vascular architecture disrupts OPC migration, while pericyte absence does not.
- Wnt-Cxcr4 signaling regulates OPC-endothelial interactions and may coordinate migration with differentiation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Oligodendrocytes myelinate axons in the central nervous system and develop from oligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and spinal cord development. We show that OPCs require the vasculature as a physical substrate for migration. We observed that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels. Migrating OPCs crawl along and jump between vessels. OPC migration in vivo was disrupted in mice with defective vascular architecture but was normal in mice lacking pericytes. Thus, physical interactions with the vascular endothelium are required for OPC migration. We identify Wnt-Cxcr4 (chemokine receptor 4) signaling in regulation of OPC-endothelial interactions and propose that this signaling coordinates OPC migration with differentiation.
The authors' abstract, as published at the source. Science, 2016 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience