Molecular Metabolism· 2015Q1· Review
Ghrelin
- 1,012citations
- Q1SCImago
- 2015year
Short summary
Ghrelin, a gastrointestinal hormone, has demonstrated a wide range of central and peripheral actions beyond its known role in energy metabolism.
AI-generated from the title and abstract; the full text is not read.
Key points
- Ghrelin's functions extend beyond energy metabolism to include cognitive and behavioral processes.
- It influences learning and memory, reward seeking, and taste sensation.
- Ghrelin also impacts gut motility, gastric acid secretion, and sleep-wake rhythms.
- The review addresses ongoing questions about ghrelin 15 years after its discovery.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
The authors' abstract, as published at the source. Molecular Metabolism, 2015 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience