Science· 2013Q1
Circadian Clock NAD <sup>+</sup> Cycle Drives Mitochondrial Oxidative Metabolism in Mice
- 652citations
- Q1SCImago
- 2013year
Short summary
Mice's circadian clock regulates mitochondrial oxidative metabolism by controlling NAD+ biosynthesis, which in turn modulates mitochondrial protein acetylation and respiration, synchronizing with daily feeding and fasting cycles.
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Key points
- Circadian clock controls NAD+ biosynthesis, creating daily cycles.
- NAD+ levels regulate mitochondrial protein acetylation and respiration.
- Circadian control of NAD+-dependent sirtuin 3 (SIRT3) is crucial for oxidative enzyme activity.
- NAD+ supplementation restored mitochondrial function in circadian mutant mice.
AI-generated from the title and abstract; the full text is not read.
Abstract
Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, and mitochondrial respiration through modulation of mitochondrial protein acetylation to synchronize oxidative metabolic pathways with the 24-hour fasting and feeding cycle. Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice. Thus, circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding.
The authors' abstract, as published at the source. Science, 2013 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience