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Science· 2013Q1

Circadian Clock NAD <sup>+</sup> Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Clara Bien Peek, Alison H. Affinati, Kathryn Moynihan Ramsey, Hsin-Yu Kuo et al.

Short summary

Mice's circadian clock regulates mitochondrial oxidative metabolism by controlling NAD+ biosynthesis, which in turn modulates mitochondrial protein acetylation and respiration, synchronizing with daily feeding and fasting cycles.

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Field: Endocrine and Autonomic Systems

Endocrine and Autonomic SystemsNeuroscience