Science· 2026Q1
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
- 1citations
- Q1SCImago
- 2026year
Short summary
The mitochondrial transporter SLC25A34 integrates circadian rhythms, diet, and temperature to control adipocyte lipid cycling by importing oxaloacetate into mitochondria.
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Key points
- SLC25A34 acts as a molecular integrator for circadian, dietary, and temperature cues in adipocyte lipid metabolism.
- The circadian clock suppresses SLC25A34 expression via REV-ERB during the sleep phase.
- Lipid-rich diets and cold exposure abolish REV-ERB repression, stimulating SLC25A34 transcription.
- SLC25A34 imports oxaloacetate, supporting the TCA cycle and cytosolic acetyl-CoA production for lipid synthesis and oxidation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid cycling. During the sleep phase, the adipocyte clock suppresses Slc25a34 expression through the REV-ERB transcriptional repressors. Entering the active phase, consuming lipid-rich diets, or exposure to cold abolishes REV-ERB repression, and lipolytic signals stimulate Slc25a34 transcription through the peroxisome proliferator–activated receptors. SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl–coenzyme A (acetyl-CoA) production. Elevated cytosolic acetyl-CoA then fuels the synthesis of lipids and promotes the transcription of genes enhancing mitochondrial oxidation. Thus, SLC25A34 confers circadian, dietary, and temperature control of adipocyte lipid metabolism.
The authors' abstract, as published at the source. Science, 2026 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience