Science· 2016Q1· Review
Mechanisms linking circadian clocks, sleep, and neurodegeneration
- 875citations
- Q1SCImago
- 2016year
Short summary
Circadian and sleep disturbances, often seen as symptoms of neurodegenerative diseases like Alzheimer's, may actually drive their early development. This review explores the cellular and molecular links between disrupted biological clocks, poor sleep, and the progression of these conditions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Circadian and sleep disturbances may initiate neurodegeneration, not just accompany it.
- The review examines cellular and molecular pathways connecting clock genes, sleep, and brain homeostasis.
- Interplay between central/peripheral rhythms and sleep impacts brain health.
- Therapeutic manipulation of circadian and sleep systems is a potential strategy for healthy brain aging.
AI-generated from the title and abstract; the full text is not read.
Abstract
Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and can profoundly affect health. Accumulating evidence indicates that circadian and sleep disturbances, which have long been considered symptoms of many neurodegenerative conditions, may actually drive pathogenesis early in the course of these diseases. In this Review, we explore potential cellular and molecular mechanisms linking circadian dysfunction and sleep loss to neurodegenerative diseases, with a focus on Alzheimer's disease. We examine the interplay between central and peripheral circadian rhythms, circadian clock gene function, and sleep in maintaining brain homeostasis, and discuss therapeutic implications. The circadian clock and sleep can influence a number of key processes involved in neurodegeneration, suggesting that these systems might be manipulated to promote healthy brain aging.
The authors' abstract, as published at the source. Science, 2016 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience