Journal of Neuroinflammation· 2014Q1· Review
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
- 1,730citations
- Q1SCImago
- 2014year
Short summary
Microglia, the CNS's resident immune cells, can be polarized into distinct activation states, including M2, but their specific functions and therapeutic potential in CNS diseases remain debated.
AI-generated from the title and abstract; the full text is not read.
Key points
- Microglia, unlike peripheral macrophages, exhibit complex polarization states whose functions are debated.
- Pro- and anti-inflammatory cytokines can induce distinct microglial activation states.
- The review examines microglial polarization in acute and chronic CNS disease models.
- M2 microglial polarization is considered a potential therapeutic target for CNS diseases.
AI-generated from the title and abstract; the full text is not read.
Abstract
The concept of multiple macrophage activation states is not new. However, extending this idea to resident tissue macrophages, like microglia, has gained increased interest in recent years. Unfortunately, the research on peripheral macrophage polarization does not necessarily translate accurately to their central nervous system (CNS) counterparts. Even though pro- and anti-inflammatory cytokines can polarize microglia to distinct activation states, the specific functions of these states is still an area of intense debate. This review examines the multiple possible activation states microglia can be polarized to. This is followed by a detailed description of microglial polarization and the functional relevance of this process in both acute and chronic CNS disease models described in the literature. Particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
The authors' abstract, as published at the source. Journal of Neuroinflammation, 2014 · DOI ↗
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Field: Neurology (Neuroscience)
NeurologyNeuroscience