The Journal of Organic Chemistry· 2026Q2
Regio- and Diastereo-Controlled (5 + 2) Cycloaddition of gem -Difluorocyclopropenes and Oxidopyridinium Ions
- 0citations
- Q2SCImago
- 2026year
Short summary
A new (5 + 2) cycloaddition method directly synthesizes 3,3-difluoro-9-azatricyclo[3.3.1.02,4]nonanes from gem-difluorocyclopropenes and oxidopyridinium ions.
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Key points
- Developed a direct (5 + 2) cycloaddition for synthesizing 3,3-difluoro-9-azatricyclo[3.3.1.02,4]nonanes.
- Utilizes gem-difluorocyclopropenes and oxidopyridinium ions as starting materials.
- Achieves moderate to good yields with exclusive exo-selectivity.
- Demonstrated synthetic utility via gram-scale reaction and derivatization.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract A method for the direct synthesis of 3,3-difluoro-9-azatricyclo[3.3.1.02,4]nonanes via a (5 + 2) cycloaddition between a gem-difluorocyclopropene and an oxidopyridinium ion is reported. This approach furnishes the products in moderate to good yields, with exclusive exo-selectivity and broad substrate compatibility. Its synthetic utility is further demonstrated by a gram-scale reaction and derivatization studies.
The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2026 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics