Science· 2016Q1· Review
How neuroinflammation contributes to neurodegeneration
- 1,975citations
- Q1SCImago
- 2016year
Short summary
Neuroinflammation, driven by changes in the brain's supportive glial cells and blood-brain barrier, is a key factor in the progression of neurodegenerative diseases like Alzheimer's and Parkinson's.
AI-generated from the title and abstract; the full text is not read.
Key points
- Neurodegenerative diseases like Alzheimer's and Parkinson's are major health concerns for aging societies.
- The brain's environment, regulated by glial cells and the blood-brain barrier, is critical for neuronal function.
- Neuroinflammation, a process involving these supportive elements, contributes to the development of neurodegeneration.
- Therapies targeting glial cells may offer potential benefits for patients with neurodegenerative disorders.
AI-generated from the title and abstract; the full text is not read.
Abstract
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most pressing problems of developed societies with aging populations. Neurons carry out essential functions such as signal transmission and network integration in the central nervous system and are the main targets of neurodegenerative disease. In this Review, I address how the neuron's environment also contributes to neurodegeneration. Maintaining an optimal milieu for neuronal function rests with supportive cells termed glia and the blood-brain barrier. Accumulating evidence suggests that neurodegeneration occurs in part because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation. These observations indicate that therapies targeting glial cells might provide benefit for those afflicted by neurodegenerative disorders.
The authors' abstract, as published at the source. Science, 2016 · DOI ↗
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Field: Neurology (Neuroscience)
NeurologyNeuroscience