Proceedings of the National Academy of Sciences· 2018Q1

Normal aging induces A1-like astrocyte reactivity

Laura Clarke, Shane A. Liddelow, Chandrani Chakraborty, Alexandra E. Münch et al.

1,317citations
Q1SCImago
2018year

Short summary

Normal aging drives astrocytes toward a neuroinflammatory A1-like reactive state, particularly in the hippocampus and striatum, a process dependent on microglial cytokines.

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Field: Neurology (Neuroscience)

NeurologyNeuroscience