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Cell Death and Disease· 2025Q1

Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm

Yuchun Wang, Minyan Ge, Jinling Wang, Yiming Xu et al.

Short summary

Ischemic stroke is driven by a metabolic crisis where acute glycolysis overdrive clashes with lipid peroxidation, causing neuroinflammation and deficits. This process involves brain-peripheral organ crosstalk and progresses through distinct phases, offering temporal therapeutic targets.

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Field: Developmental Neuroscience

Developmental NeuroscienceNeuroscience