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Proceedings of the National Academy of Sciences· 2013Q1

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

Jennifer L. Pluznick, Ryan J. Protzko, Haykanush Gevorgyan, Zita Peterlin et al.

Short summary

A kidney-expressed olfactory receptor, Olfr78, responds to gut microbiota-derived short-chain fatty acids (SCFAs) and mediates renin secretion, influencing blood pressure regulation in mice.

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Field: Sensory Systems

Sensory SystemsNeuroscience