Organic Letters· 2026Q1
Catalytic Desymmetrizing Carbonyl–Amine Condensation Reaction to Construct Axially Chiral Diaryl Ethers
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- 2026year
Short summary
A novel catalytic desymmetrizing carbonyl–amine condensation (CAC) reaction enables the highly enantioselective synthesis of axially chiral diaryl ethers, achieving up to 99% ee.
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Key points
- Developed a catalytic desymmetrizing carbonyl–amine condensation (CAC) reaction.
- Achieved highly enantioselective synthesis of axially chiral diaryl ethers (up to 99% ee).
- First application of prochiral aromatic amines in asymmetric CAC reactions.
- Cyclobutane-1,3-diones demonstrated superior reactivity and enantioselectivity.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Catalytic desymmetrizing carbonyl–amine condensation (CAC) reactions between prochiral 2,6-diamino diaryl ethers and cyclobutane-1,3-diones have been developed for the highly enantioselective synthesis of axially chiral diaryl ethers in up to 99% ee values. This reaction represents the first application of prochiral aromatic amines in catalytically asymmetric CAC reactions. Control experiments revealed that cyclobutane-1,3-diones showed an obviously higher reactivity and enantioselectivities in these asymmetric CAC reactions.
The authors' abstract, as published at the source. Organic Letters, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry