Immunological Investigations· 2026Q2· Review
Rewiring Food Allergy Management: From Allergen Detection to Immune Engineering Therapies
- 0citations
- Q2SCImago
- 2026year
Short summary
New immune engineering strategies, including virus-like particle vaccines and microbiome-augmented protocols, show promise for achieving sustained unresponsiveness in food allergies, moving beyond current desensitization therapies.
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Key points
- Advanced diagnostic tools like multi-omics and portable biosensors are improving allergen detection accuracy and on-site applicability.
- Current allergen-specific immunotherapies provide desensitization but are limited by inconsistent efficacy, safety, and sustainability.
- Biologics such as omalizumab and dupilumab expand treatment options for food allergies.
- Next-generation therapies, including virus-like particle vaccines and microbiome-augmented protocols, aim for sustained immune unresponsiveness.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND: Food allergy represents a growing global health challenge, particularly among children in developed countries. Despite decades of research, major barriers persist in both allergen detection and durable immune intervention. METHODS: This review synthesizes current diagnostic and therapeutic strategies in food allergy, critically evaluates their mechanistic underpinnings and translational readiness. RESULTS: Traditional immunoassays (e.g. enzyme-linked immunosorbent assay, immunoblotting) are sensitive but hindered by matrix interference, operational complexity, and limited real-world applicability. Recent innovations - multi-omics, DNA-based platforms, and portable biosensors - are advancing allergen surveillance toward precision, on-site detection. In parallel, allergen-specific immunotherapies have emerged as proactive strategies for desensitization, yet vary in efficacy, safety, and sustainability. Biologics (e.g. omalizumab, dupilumab) have broadened treatment options, while next-generation platforms - virus-like particle vaccines and microbiome-augmented protocols - are unlocking novel paths toward sustained unresponsiveness. CONCLUSIONS: This review outlines an emerging framework of immune engineering poised to redefine the future of allergy care.
The authors' abstract, as published at the source. Immunological Investigations, 2026 · DOI ↗
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Field: Immunology and Allergy
Immunology and AllergyMedicine