The Journal of Organic Chemistry· 2026Q2
Electrochemical Trifluoromethylation of Alkenes Using the Unpurified CF3I Reagent from Fluoroform
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- Q2SCImago
- 2026year
Short summary
A new electrochemical method converts fluoroform (HCF3), a greenhouse gas, into CF3I, which is then used directly to trifluoromethylate alkenes with yields comparable to commercial CF3I.
AI-generated from the title and abstract; the full text is not read.
Key points
- Fluoroform (HCF3) is converted to CF3I via an electrochemical process.
- The generated CF3I is used directly for alkene trifluoromethylation.
- Yields are comparable to those using commercial CF3I reagents.
- Iodine residues in the in-situ generated CF3I can enhance reactivity in some instances.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Fluoroform (HCF3) is an excess industrial gas with a significant greenhouse effect. The utilization of fluoroform as the trifluoromethyl precursor could turn the waste into a value-added product. In this work, we report a protocol for converting fluoroform to CF3I, which was used directly in the electrochemical trifluoromethylation of alkenes facilitated by the orthogonal reactivity in two steps. This protocol could give the trifluoromethylated products in comparable yield to those obtained with a commercial CF3I solution. In particular, the iodine residue in the prepared CF3I has a positive effect in some examples, with advantages over commercial CF3I reagents.
The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2026 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics