Pharmaceutics· 2026Q1
Development and Characterization of Lysozyme-Loaded Gum Arabic as Buccal Films
- 0citations
- Q1SCImago
- 2026year
Short summary
Optimized gum arabic (GA) films loaded with lysozyme achieved a breaking hardness of 10.8 N, disintegrated in 2.98 min, and maintained 1.5% moisture content, showing potential as mucoadhesive buccal drug carriers.
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Key points
- Lysozyme-loaded gum arabic (GA) films were developed and optimized using a 2^3 factorial design.
- The optimized formulation achieved a breaking hardness of 10.8 N, indicating adequate flexibility.
- The optimized films demonstrated rapid disintegration in an average of 2.98 minutes.
- Moisture content was approximately 1.5%, contributing to film flexibility and handling.
AI-generated from the title and abstract; the full text is not read.
Abstract
Methods: Lysozyme-loaded gum arabic (GA) films were developed using a solvent-casting method and optimized through a 23 full factorial design to evaluate the effects of GA, citric acid (CA), and propylene glycol (PG) on film performance. Dependent variables included breaking hardness, mucoadhesivity, film thickness, moisture content, surface free energy (SFE), water uptake percentage, and disintegration time. A comprehensive set of evaluations was performed, including mechanical testing, mucoadhesion measurements, moisture and hydration analysis, disintegration time and surface free energy determination. Results: Mechanical testing revealed adequate flexibility, with breaking hardness values of a minimum of 10.8 N in the optimized formulation. Moisture content remained within an acceptable range, reaching approximately 1.5%, which contributed to suitable flexibility and handling. Disintegration testing showed rapid hydration behavior, with the optimized film disintegrating in an average of 2.98 min. Statistical analysis identified significant effects of GA, CA, and PG concentrations on several properties individually or interacting with each other, enabling the selection of an optimal combination that balanced mechanical integrity and mucoadhesivity. Conclusions: Overall, the optimized GA-based films demonstrate strong potential as a new effective mucoadhesive carrier for lysozyme delivery.
The authors' abstract, as published at the source. Pharmaceutics, 2026 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics